Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 7th Annual Summit on Microbiology: Education, R&D and Market San Antonio, Texas, USA.

Day 2 :

Keynote Forum

Xhavit Zogaj

University of Texas at San Antonio, USA

Keynote: Construction of a live vaccine strain against Tularemia
OMICS International Microbiology Conference 2018 International Conference Keynote Speaker Xhavit Zogaj photo
Biography:

Xhavit Zogaj is working as an Asst Prof of Research in Biology department of the University of Texas at San Antonio, Texas, USA. His area of specialization is Vaccine development against tularemia and Bacterial Biofilms. His areas of specialization are Vaccine development against tularemia, and Bacterial Biofilms.

Abstract:

Francisella tularensis subsp. tularensis (Ftt) is a highly virulent bacterium that causes the disease tularemia. Fewer than 10 bacteria are sufficient to cause a fatal infection when the bacteria are inhaled into the lung, therefore Ftt has been classified as a category A biothreat agent. F. novicida (Fn) is a closely-related species that is avirulent in healthy humans but causes a fatal disease in mice. We are developing Fn as a live vaccine strain to protect against Ftt infection. We have already shown that Fn with a mutation in iglD, the T6SS gene required for phagosome escape and intramacrophage replication (Fn-iglD), protects vaccinated animals against pulmonary challenge with Ftt using two different animal models, the Fischer 344 rat, and the cynomolgus macaque. To enhance the efficacy of Fn-iglD, we have engineered it to express the LPS O-antigen from Ftt (OAgFTT). The Fn-iglD strain expressing OAgFTT, KKF768, induces antibodies against OAgFTT in vaccinated mice and rats. Moreover, KKF768 vaccinated Fischer 344 rats are protected against lethal pulmonary challenge with Ftt, demonstrating that Fn iglD/OAgFTT is a good candidate for a tularemia vaccine.

Keynote Forum

Salina Parveen

University of Maryland Eastern Shore, USA

Keynote: Salmonella: An enemy for poultry industry
OMICS International Microbiology Conference 2018 International Conference Keynote Speaker Salina Parveen photo
Biography:

Salina Parveen is a Professor in Food Science and Technology Program, at the University of Maryland Eastern Shore, MD, USA. She holds a BS in Botany and an MS in Microbiology from the University of Dhaka, Bangladesh and a PhD in Food Science and Human Nutrition, specializing in Microbiology and Molecular Biology from the University of Florida, FL, USA. She teaches graduate level courses in Microbiology and Toxicology. Her research interests are Food and Environmental Microbiology, Food Safety, and Water Quality. She has an excellent record of grantmanship and received several awards for outstanding academic performance. She has published numerous peer-reviewed journal articles and book chapters, and presented her research findings at various regional, national and international professional meetings. She also serve on several national and international scientific committees and the Editorial Board member of many peer-reviewed journals.

Abstract:

Statement of the Problem: Salmonella infection or salmonellosis is a global public health problem and is one of the major causes of bacterial food-borne illnesses in the United States, causing an estimated 1.2 million illnesses, 23,000 hospitalizations, and 450 deaths per year. Food of animal origin, especially poultry and poultry products, are one of the major vehicles of salmonellosis. Methodology: Salmonella was recovered from chicken carcasses, confirmed and characterized using phenotypic and genotypic methods. Findings: This bacterium is widely distributed on chicken carcasses and its incidence differs among parts, with rib back and sacral back being the most contaminated. The most common serotypes isolated from chicken during our study were Salmonella typhimurium and S. Kentucky. Studies have demonstrated that processing conditions, such as the chilling process, can be a significant source of Salmonella contamination between carcasses. Recent reports on the recovery of multidrug-resistant (MDR) and genetically diverse S. typhimurium and S. Kentucky from commercially processed chicken carcasses raised serious concern about overall management practices. Studies have also revealed that chilling in chill tanks may play a significant role in promoting the selection of antimicrobial resistant pathogens during poultry processing. Whole genome sequencing of the MDR S. typhimurium and S. Kentucky strains confirmed that they shared serovar-specific conserved coding sequences, although several genomic regions with significant mismatch were detected. Phenotype microarray and intracellular killing assay results suggest that S. typhimurium is capable of utilizing certain carbon compounds at a higher rate, and can survive better and be more invasive than S. Kentucky in macrophages and chicken granulosa cells.
Conclusions and significance: To prevent Salmonella infection, it is important to assure that poultry and poultry products are not contaminated with this bacterium. Therefore, active monitoring systems and control strategies must be established from farm to fork.